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KMID : 0985520060110020127
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Korean Journal of Pancreas and Biliary Tract
2006 Volume.11 No. 2 p.127 ~ p.129
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Pancreatic Exocrine and Endocrine Cell Differentiation during Pancreatic Regeneration
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Park In-Sun
Lee Song
Hong Seok-Woo
Eom Jae-Hyun
Lim Woo-Chul
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Abstract
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Pancreatic tissue is maintained by a simple proliferation of the preexisting cells in adulthood, whereas they are dynamically derived from precursor/stem cells from ductal epithelia during prenatal life. It has been known that tissue regeneration occurs rarely in normal adult pancreas particularly in human pancreas.However, regeneration can be experimentally induced in adult pancreas in response to various tissue injuries such as partial resection, pancreatitis by obstruction of the duct and chemical insults.1,2 It may imply that stem/precursor cells could be recapitulated and regenerated the functional cells including endocrine and exocrine pancreatic cells including acinar and ductal cells.
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